Polynucleotides (Plinest™) – Regenerative Skin Rejuvenation Treatment in Jesmond, Newcastle
What Are Polynucleotides, and What Is Plinest™?
Polynucleotides-“salmon sperm facial” are long chains of nucleotides (the building blocks of DNA and RNA) that in aesthetic medicine act as bio-stimulators rather than volumisers. They are extracted from the gonads of Trout or Salmon.
They help promote cellular repair, collagen and elastin synthesis, hydration, and modulation of inflammation.
PlinestTM (by Mastelli, marketed via DermaFocus in the UK) is a brand of highly purified polynucleotides using PN-HPTTM (Polynucleotide High Purity Technology). The purification process aims to maximise biocompatibility and safety.
PlinestTM comes in different formulations (e.g. Plinest, Plinest Eye, Plinest Hair, Newest) optimised for different areas or depths of treatment.
Course of Treatment / Protocol
| Initial “loading” phase | 2 to 4 sessions | 2–4 weeks apart (often ~3 weeks) | To “kick-start” regenerative processes and build a baseline improvement |
| Observation / consolidation | – | – | Allow time for collagen remodelling and effect development (often visible 4–8 weeks after start) |
| Maintenance phase | 1 session every 6–12 months (often every 6-9 months) | – | – |
Where They Are Used / Indications
Polynucleotides like PlinestTM are used to improve skin quality rather than to provide significant immediate volume. Typical applications include:
Face: overall skin texture, fine lines, crepiness, nasolabial and perioral areas
Under-eye / periorbital: dark circles, fine lines, lid lift / lower eyelid region
Neck & décolletage: improves laxity, texture, hydration in more delicate areas
Hands, inner arms, thighs, and other body areas with crepey skin or laxity
Scars & stretch marks: for skin regeneration and improved texture over time
Scalp / hair: Plinest™ formulations are used in the scalp to support hair health, hair density, increase hair growth and for pre and post hair transplant support.
Because polynucleotides act by stimulating tissue regeneration rather than filling, results tend to develop gradually.
Maintenance & Longevity
- Typically, 1 maintenance session every 6–9 months is recommended to preserve and build upon results.
- Some patients may prefer more frequent sessions (e.g. every 6 months) especially in areas of faster aging or greater environmental stress.
- If a patient delays maintenance too long, you may “restart” a mini course.
- Combining with complementary therapies (e.g. microneedling, Profhilo Bioremodellers) can often enhance and prolong results (but this must be tailored per patient).
- Ongoing good skincare (sun protection, antioxidants, hydration) supports longevity.
Downtime / Recovery
One of the advantages of polynucleotide treatments is their relatively low downtime. Typical recovery profile:
Side Effect | Duration | Management & Advice |
Redness / erythema | Minutes to a few hours, occasionally up to 24 h | Use cool compresses; avoid heat & harsh skincare immediately after |
Swelling (mild) | 1–2 days | Cold compress, avoid heavy exertion, keep head elevated if significant |
Bruising / petechiae | 1–5 days (variable) | Gentle care, arnica, vitamin K cream, topical camouflage if needed |
Tenderness or mild discomfort | 24–48 hours | Analgesics (ibuprofen/acetaminophen as appropriate), gentle skincare |
Minimal risk: infection, nodules, adverse reaction | Rare |
In most patients, normal activities (non-strenuous) can be resumed the same day or the next day, and makeup may be applied after a few hours (if no open bleeding or skin sensitivity). We would advise avoiding heavy exercise, sauna, hot baths, or direct sun for 24–48 hours.
Overall, downtime is minimal and typically well tolerated.
What Patients Can Expect (Timeline of Results)
Immediately after treatment, the skin may look fresher, plumper (some hydrating effect), slight redness.
Over the next 2–4 weeks, regeneration begins, hydration and microtexture may improve.
By 8–12 weeks, more noticeable improvements in fine lines, firmness, tone, and skin quality tend to manifest.
Some improvements may continue beyond 3 months as collagen remodelling continues.
The peak effect may stabilize and gradually diminish over time, which is why maintenance is important.
Many patients show consistent improvements in fine lines, radiance, firmness after full courses of treatment.
Treatment Length / Duration of Session
- A typical session for a full-face or face + neck may take 20 to 45 minutes depending on area, skin condition, number of injection points, and complexity.
- Smaller zones (e.g. periorbital, limited areas) may take only 10–20 minutes.
- Preparation (cleansing, numbing) and post-treatment care add a bit of time overhead, so total clinic time is usually 30–60 minutes.
Get in Touch
We are always on hand to answer any questions you may have about our treatments.
Book a consultation
If you’re considering polynucleotides in Jesmond, Newcastle and want expert advice tailored to your needs, we’re here to help. Our focus is on providing honest, transparent guidance and delivering results that leave you looking refreshed, confident, and completely yourself.
Book a consultation today to discover how polynucleotides can help you achieve your aesthetic goals.
Frequently Asked Questions
What exactly are polynucleotides?
Polynucleotides (the “salmon sperm facial”) are natural DNA fragments derived from salmon or salmon trout gonads that act as powerful skin bio-stimulators.
Rather than filling or freezing lines, they encourage your skin’s own cells to repair, hydrate, and rebuild collagen and elastin.
This creates smoother, firmer, and more radiant skin over time.
What is Plinest?
Plinest® is a medical-grade polynucleotide injectable developed in Italy using PN-HPT® technology (High Purity Technology). It’s one of the most studied and trusted polynucleotide brands worldwide, known for its purity, safety, and regenerative results.
Plinest can be tailored for different areas of concern-face, eyes, neck, hands, or scalp.
How does it work?
Once injected into the skin, polynucleotides:
- Stimulate fibroblast activity, encouraging new collagen and elastin production.
- Improve hydration by binding water molecules within the skin.
- Support tissue repair and reduce inflammation.
- Improve cell turnover and the overall health of your skin.
This process restores structure and vitality from within, giving long-lasting natural rejuvenation.
Which areas can be treated with Plinest?
Polynucleotides are extremely versatile and can safely treat:
- Full face (fine lines, dull or crepey skin)
- Under-eye area and eyelids
- Neck and décolletage
- Hands and inner arms
- Scalp (to strengthen hair and support growth)
- Stretch marks or scarred skin
How many sessions will I need?
For best results, a course of 3 treatments spaced 3-4 weeks apart is usually recommended.
Results are progressive, and improvements continue to develop for several months after your final session.
Once you’ve completed your initial course, a maintenance treatment every 6–9 months helps to sustain and build on your results.
Is the treatment painful?
Discomfort is minimal. A topical numbing cream can be applied before your procedure, and the injections are performed using very fine needles. Most patients describe the treatment as a mild stinging or pressure sensation.
How long does a session take?
Depending on the treatment area, a Plinest session usually takes 30-45 minutes, including consultation, numbing, and the injections themselves.
What is the downtime?
Downtime is minimal. You may experience some redness, small bumps, or mild swelling at the injection sites- these typically settle within a few hours to 48 hours. Bruising is possible but uncommon. Most patients return to normal activities immediately or the next day.
When will I see results?
Some people notice a fresh, hydrated glow within days, but the real transformation develops gradually as your skin regenerates.
Expect to see visible improvements in texture, elasticity, and tone from 4-8 weeks, with continued improvement for several months.
How long do results last?
Results typically last 6-12 months, depending on your age, skin quality, and lifestyle. Maintenance treatments once or twice a year help prolong your results.
Can I combine Plinest with other treatments?
Yes. Plinest works beautifully alongside other regenerative and aesthetic treatments such as:
- Microneedling
- Profhilo
- Laser or radiofrequency skin rejuvenation
Your treatment plan can be tailored to your skin goals during consultation.
